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Sinai, will analyze whether applying topicals in different orders changes their efficiency. Kornreich will also study the safety and effectiveness of a holistic treatment in moderate to severe plaque psoriasis. Marina Li, B.S., a third-year medical college student at Case Western Reserve University, will examine whether reducing skin inflammation also reduces blood clots and other indications of cardiovascular disease. Forum Patel, M.D., of the University of California, Davis, will determine if complex sugars called glycans are biomarkers, or biological indications, of psoriasis. Scott Santilli, M.D., of University Medical center Case INFIRMARY, will examine the effect of systemic, or whole-body, psoriasis therapy and its potential to regulate cardiovascular risk in people with psoriasis.