It seems sensible then that the nutrients required by the adrenals to produce adrenal hormones are also depleted. Eventually the adrenals become exhausted and commence to produce inadequate levels of the hormones that maintain us energised and feeling alive. Adrenal Exhaustion – Common Symptoms and Causes The normal symptoms of adrenal exhaustion include the following – Trouble getting up each morning even after 8 hours sleep Chronic tiredness on waking and through the day Difficulty completing duties and thinking clearly Craving for salt Low blood pressure especially on standing Other causes of fatigue should be ruled out by your health practitioner before a analysis could be made.In 2008, ANAVEX programs to expand its scientific collaborations to add major U.S. Study and academic organizations. Pipeline Highlights ANAVEX’s SIGMACEPTOR-N plan pipeline is focused on developing disease-modifying treatments for neurological conditions. Substantial advancements have been made out of ANAVEX 1-41. In recent pre-clinical animal studies, the compound demonstrated significant neuroprotective benefits through the prevention of oxidative stress, which damages and destroys cells and is usually believed to be a main cause of Alzheimer’s disease. The novel system of actions of ANAVEX 1-41 demonstrates that the compound may influence the course of Alzheimer’s disease and prevent or limit the creation of plaques that destroy brain cells in the hippocampus, the area of the mind that regulates learning, memory and emotion.