Emails or online communications.

It’s poor enough when the common citizen has given up on the idea that it is wrong for our authorities to spy on us, but when users of the press accept surveillance as a known fact of life, it would seem to indicate that our society is in deep problems. Although most investigative reporters state that the spying has not affected their reporting, a substantial %age admit that they have altered their journalistic approach. From the Pew record: Simply 14 percent say that during the past 12 months, such worries have kept them from going after a story or reaching out to a particular source, or have led them to altogether consider leaving investigative journalism.We hypothesized that PLS3 may be involved in mechanosensing of osteocytes. Mechanical loading in the form of fluid shear tension increases the creation of nitric oxide in bone cells,13 periodontal ligament, and gingival fibroblasts.14 In the lack of bone tissue from patients, we investigated the response to fluid shear stress of dermal fibroblasts from six patients with PLS3 mutations, in comparison with three patients with molecularly confirmed osteogenesis imperfecta type I and eight controls. To characterize the effect of loss of PLS3 on bone morphology, we performed morpholino-mediated knockdown of the zebrafish homologue .15 Information on these studies are given in the Supplementary Appendix.

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