Statistical Evaluation We calculated that a sample of 400 patients would provide 80 percent power to detect a relative difference of 50 percent in the primary outcome, at a two-sided alpha level of 0.05, assuming a 20 percent rate of postoperative complications in the nonprotective-ventilation group.25 For safety reasons, an interim evaluation was conducted following the enrollment of the first 200 patients, based on the a priori statistical evaluation plan. The info and security monitoring committee did not recommend discontinuation of the trial based on that analysis, and 400 patients were included therefore.His notes have been rendered uselessly homogeneous by the tyranny of clicks and auto-populated fields. I can’t even picture their faces. The blanks on our displays can be filled with phrases, but the process of understanding cannot be auto-populated. Life without the EHR will be unimaginable Perhaps. But the technology will support and improve medical care only if it evolves in ways that help, rather than hinder, us in synthesizing, examining, thinking critically, and informing the whole stories of our individuals.