Although this mean change did not exceed the minimal important difference of at least 4 units clinically, more individuals in the azithromycin group than in the placebo group experienced a loss of at least 4 units in their SGRQ score . No consistent adjustments were observed in the ratings on the SF-36 . The suggest rate of adherence to the study medication was 67.3 percent in the azithromycin group and 66.9 percent in the placebo group . Subgroup Analyses Analyses were performed according to 22 subgroups; the email address details are provided in Section I in the Supplementary Appendix.No futility evaluation was performed, just because a result indicating a minimal difference between the treatment groups was regarded as important, and maximum accuracy in this situation was deemed to be desirable. The trial was not stopped prematurely. Owing to the type of the intervention, it was not possible to conceal the procedure assignments from the individuals, the local study nurses, or the investigators. However, the staff who performed the statistical evaluation were not aware of the treatment assignments.