Scott Overcash.

G. Ralph Corey, M.D ., Heidi Kabler, M.D., Purvi Mehra, M.D., Sandeep Gupta, M.D., J. Scott Overcash, M.D., Ashwin Porwal, M.D., Philip Giordano, M.D., Christopher Lucasti, M.D., Antonio Perez, M.D., Samantha Good, Ph.D., Hai Jiang, Ph.D., Greg Moeck, Ph.D., and William O’Riordan, M.D. For the SOLO I Investigators: Single-Dose Oritavancin in the Treatment of Acute Bacterial Skin Infections The economic burden of severe bacterial skin and skin-structure infections remains substantial1 and is powered by the high costs of hospitalization2,3 and by treatment with agents that require dosing once or twice daily for a duration of 7 to 10 times or even more.2,4-12 Treatment of these infections often requires agents that are active against methicillin-resistant Staphylococcus aureus , which is still a significant causative pathogen in many countries.13,14 Even treatment within an outpatient establishing cannot overcome the disadvantage of multiple administrations, incomplete adherence to medicine regimens,15 and the complexity of monitoring therapeutic medication levels.16 Oritavancin is a lipoglycopeptide antibiotic with 3 mechanisms of action17-19 that result in concentration-dependent bactericidal activity20 against clinically relevant gram-positive pathogens.21-23 Oritavancin has a prolonged terminal half-lifestyle24 and is excreted unchanged in both feces and urine.

Key research areas for the products include: Oncology, Regenerative Medicine, Environmental Analysis, Cytotoxicity Screening, Stem and Glycomics Cell Biology.. 3D Spheroid Cell Proliferation Assays introduced by AMSBIO AMSBIO has introduced a new range of 96-well file format 3D Spheroid Cell Proliferation / Viability Assays, providing a new tool to allow cell-based assays to be carried out in 3D. The brand new AMSBIO 3D Spheroid Proliferation/Viability Assay provides a useful tool for modeling tumor response in vitro. The package utilises a 3D Culture Qualified 96 Well Spheroid Formation Plate alongside a specialised Spheroid Formation Extracellular Matrix to drive aggregation and/or spheroid formation of cells. Upon completion of spheroid development, the spheroid may be treated with pharmacological agents to evaluate tumor viability after medications.

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