In such cases fast reopening of the infarct vessel may be the main aim of treatment. This ‘reperfusion’ therapy has been shown to save lives, especially when applied with 2-3 hours after the onset of infarction. Recanalisation of the infarct vessel can be obtained by administering thrombolytic brokers or by executing a mechanical recanalisation accompanied by angioplasty of at fault lesion . Major PCI can open significantly more vessels than thrombolytic therapy, and for that reason save more lives, but it can only be performed in services with a cath laboratory and a skilled team on stand-by. Obtaining patients with an AMI to a PCI centre in the shortest feasible time is a significant challenge which requires a close collaboration between cardiologists of different hospitals and the crisis medical system.Florida Laura Joanne Bratcher, RN, BSN, CCRN-CSC, CNML Nurse Supervisor, Pediatrics, Shands Children’s Hospital at the University of Florida, Gainesville Maryland Helen F. Dark brown, MS, BC-ACNP, BC-FNP Nurse Practitioner, Emergency Section, Anne Arundel Medical Center, Annapolis, Md. Clinical Instructor, ACNP / FNP programs, Georgetown University School of Health and Nursing Studies, Washington, D.C. Massachusetts Jeanne P. Ahern, RN, BSN, MHA, CCRN Nurse Supervisor, Cardiovascular ICU, Children’s Medical center Boston Maria E. Bentain-Melanson, RN, MSN, CCRN-CSC Nursing Clinical Educator for Cardiac Medical operation ICU, Brigham and Women’s Hospital, Boston Patricia A. Lincoln, RN, MS, CNS-BC, CCRN Clinical Nurse Expert, Cardiac ICU, Children’s Medical center Boston Michigan Kathleen M.