In the evaluation of the correlation between EV71 neutralizing antibody amounts and disease protection, little variation was seen in the sum of specificity and sensitivity values for neutralizing antibody titers of just one 1:8 to 1 1:32. A titer of just one 1:16 got the maximum summed sensitivity and specificity ideals , and this titer might be considered as a possible serologic marker for protection against EV71-linked hand, foot, and mouth disease or herpangina in vaccinated children. Discussion The EV71 vaccine showed efficacy against EV71-associated hand, foot, and mouth disease or herpangina and EV71-associated hospitalization or serious cases of hand, foot, and mouth disease .Follow-up Electrocardiography was performed with the individual in rest, and the creatine kinase level and the MB fraction of creatine kinase were measured in all patients before angiography was performed and between 12 and 24 hours after enrollment. Follow-up appointments were scheduled at 1 and six months and at 1, 2, 3, 4, and 5 years.21 Furthermore, we performed resting ECG, measured the known levels of total cholesterol and cholesterol fractions, and assessed the patient’s utilization of medical resources. End Points The prespecified primary end point was a composite of death from any trigger, nonfatal myocardial infarction, or unplanned hospitalization resulting in urgent revascularization through the first 2 years.